ABSTRACT
A practical synthesis of ellagic acid has been achieved from methyl gallate by a proposed synthetic route of five steps, consisting of ketal protection, regioselective bromination, bis-lactonization, C-C bond formation between the aromatic rings of the galloyl groups, and ketal deprotection, in 38% overall yield. Ellagic acid showed a slight inhibitory activity against SARS-CoV-2 3CLpro. © 2022. Thieme. All rights reserved.
ABSTRACT
A practical synthesis of ellagic acid has been achieved from methyl gallate ester by a proposed synthetic route of five steps, ketal protection, regioselective bromination, bis-lactonization, C-C bond formation between the aromatic rings of galloyl groups, and ketal-deprotection in 38% overall yield. Ellagic acid showed a slight inhibitory activity on the SARS-CoV-2 eCLpro protease. © 2022 Georg Thieme Verlag. All rights reserved.